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Fingerprint Spectral Signatures Revealing the Spatiotemporal Dynamics of Bipolaris Spot Blotch Progression Article

Fengle Zhu, Zhenzhu Su, Alireza Sanaeifar, Anand Babu Perumal, Mostafa Gouda, Ruiqing Zhou, Xiaoli Li, Yong He

Engineering 2023, Volume 22, Issue 3,   Pages 171-184 doi: 10.1016/j.eng.2022.10.006

Abstract: Therefore, the dynamic characterization of early pathogen progression is crucial for disease monitoringThe early spectral and biochemical responses of barley leaves to spot blotch progression were also investigatedinterpretable and could capture the unique characteristics of chlorotic and necrotic tissues along with lesionprogression, enabling the in situ visualization of the spatiotemporal dynamics of early plantalterations, the extracted FSSs successfully tracked the spatiotemporal dynamics of bipolaris spot blotch progression

Keywords： Hyperspectral imaging     Fingerprint spectral signatures     Spot blotch     Leaf lesion progression     Presymptomatic    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCC) tissues. We previously showed that ALDOB inhibited proliferation through a mechanism independent of its enzymatic activity in ccRCC, but the mechanism was not unequivocally identified. We showed that the corepressor C-terminal-binding protein 2 (CtBP2) is a novel ALDOB-interacting protein in ccRCC. The CtBP2-to-ALDOB expression ratio in clinical samples was correlated with the expression of CtBP2 target genes and was associated with shorter survival. ALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial marker genes. Furthermore, ALDOB overexpression decreased the proliferation and migration of ccRCC cells in an ALDOB-CtBP2 interaction-dependent manner. Mechanistically, our findings showed that ALDOB recruited acireductone dioxygenase 1, which catalyzes the synthesis of an endogenous inhibitor of CtBP2, 4-methylthio 2-oxobutyric acid. ALDOB functions as a scaffold to bring acireductone dioxygenase and CtBP2 in close proximity to potentiate acireductone dioxygenase-mediated inhibition of CtBP2, and this scaffolding effect was independent of ALDOB enzymatic activity. Moreover, increased ALDOB expression inhibited tumor growth in a xenograft model and decreased lung metastasis in vivo. Our findings reveal that ALDOB is a negative regulator of CtBP2 and inhibits tumor growth and metastasis in ccRCC.

Keywords： ALDOB     kidney cancer     cell proliferation    

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Characteristics of night soil and leaf co-composting using aerobic static method

Xiaojie SUN, Dunqiu WANG, Wenjing LU, Hongtao WANG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 3,   Pages 421-427 doi: 10.1007/s11783-011-0380-9

Abstract: The main purpose of this work is to investigate the characteristics of night soil and leaf co-compostingThree influencing factors, including proportion of night soil and leaf, aeration rate and aeration patternIt was found that the 3∶1 (w∶w) mixture of night soil and leaf was capable of achieving the highest composting0.14 m ·min ·m aeration rate was most beneficial to composting, and the mixture of night soil and leaf

Keywords： night soil     leaf     aerobic compost     aeration rate     aeration pattern    

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems and , an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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percutaneous coronary intervention of left main coronary artery disease: the importance of proper lesion

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 75-84 doi: 10.1007/s11684-022-0950-1

Abstract: who underwent percutaneous coronary intervention (PCI) for a de novo left main coronary artery lesioncardiovascular events (MACEs) including cardiac death, non-fatal myocardial infarction, and target lesionThe cohort was divided into two groups depending on weather the lesion preparation was done accordingIf the lesion preparation was done according to the guidelines, the MACE and TLR rates were 21.2lesion

Keywords： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary    

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Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 223-228 doi: 10.1007/s11684-017-0517-8

Abstract: this study is to guide a triage for the management of cervical high-grade squamous intraepithelial lesionThe rate of residual lesion was calculated, and the factors associated with residual lesion were analyzed

Keywords： cervical high-grade squamous intraepithelial lesion     conization     positive surgical margin     hysterectomy    

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Lateral progression of brachial plexus avulsion injury

GU Yudong

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 20-23 doi: 10.1007/s11684-007-0004-8

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract: number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The interaction by co-stimulatory molecules 4-1BB and 4-1BB ligand (4-1BBL) plays an important role in the activation, proliferation and differentiation of T lymphocytes. The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapy efforts. In this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in lymphocyte activation and tumor suppression was investigated. The plasmid p4-1BBL containing the full length of mouse 4-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cells and murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscle directly. The study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation and cytotoxicity of lymphocytes, and it could increase the expression level of IL-2 and IFN-γ. The treatment with plasmid p4-1BBL revealed that the number of CD8 T cells in the peri-tumoral tissue increased markedly, and the growth rate of the tumor was significantly lower than that of control group. These findings suggest that expression of 4-1BBL by normal cells in the tumor microenvironment can enhance the proliferation and other functions of T lymphocytes. This therapeutic method may provide a promising approach for tumor immunotherapy.

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 85-90 doi: 10.1007/s11684-016-0435-1

Abstract: linked to atherogenesis, but there is little in vivo evidence for its role in the progressionWe evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activationDuring follow-up, 13 patients (13%) developed progression of CAD.intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progressionmonocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression

Keywords： coronary artery disease     inflammation     integrin     myeloperoxidase     leukocyte activation    

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5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: tRNA-derived small RNAs (tsRNAs) are novel non-coding RNAs that are involved in the occurrence and progression> derived 5′-tiRNA-Gln, is significantly downregulated, and its expression level is correlated with progressiondownregulated proteins include ARAF, MEK1/2 and STAT3, causing the impaired signaling pathway related to HCC progressionthe intramolecular G-quadruplex structure, and this process partially inhibits translation and HCC progression

Keywords： EIF4A1     G-quadruplex     hepatocellular carcinoma     tRNA-derived small RNA     translation initiation    

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Seasonal variations in leaf capturing of particulate matter, surface wettability and micromorphology

Huixia WANG, Hui SHI, Yangyang LI, Ya YU, Jun ZHANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 4,   Pages 579-588 doi: 10.1007/s11783-013-0524-1

Abstract: The seasonal changes in leaf particulate matter (PM) accumulation, surface wettability and micromorphologyDuring the study, the leaf PM retention amount of , a species with ridged leaf surfaces, was significantlyhigher than that of and , species with waxy leaf surfaces.The contact angles of water droplets on leaves decreased with leaf age except on the abaxial surfaceA significant and negative relationship existed between leaf PM retention amounts and contact angles

Keywords： contact angle     particulate matter     retention amount    

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: However, the functional significance of NETO2 in melanoma progression remains unclear.Overall, this study uncovered the crucial role of NETO2-mediated regulation in melanoma progression,

Keywords： melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

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Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 204-206 doi: 10.1007/s11684-008-0039-5

Abstract: The aim of this paper is to study the changes of apoptosis and cell cycle progression in HeLa cells after(FCM) was used to examine the PARP expression and the percentage of apoptotic cells and cell cycle progression

Keywords： control     irradiation     apoptotic     progression     3-AB    

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Identification and selection of resistance to

Lizhen ZHU, Jianying LI, Zhongping XU, Hakim MANGHWAR, Sijia LIANG, Suli LI, Muna ALARIQI, Shuangxia JIN, Xianlong ZHANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 236-252 doi: 10.15302/J-FASE-2018223

Abstract: Whitefly-resistance index determination showed that a leaf having a high density of hairs had resistanceLonger leaf hairs were also important for resistance.

Keywords： Bemisia tabaci     Gossypium genotypes     gossypol     leaf hair density     leaf hair length    

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Title Author Date Type Operation

Fingerprint Spectral Signatures Revealing the Spatiotemporal Dynamics of Bipolaris Spot Blotch Progression

Fengle Zhu, Zhenzhu Su, Alireza Sanaeifar, Anand Babu Perumal, Mostafa Gouda, Ruiqing Zhou, Xiaoli Li, Yong He

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

Characteristics of night soil and leaf co-composting using aerobic static method

Xiaojie SUN, Dunqiu WANG, Wenjing LU, Hongtao WANG

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

percutaneous coronary intervention of left main coronary artery disease: the importance of proper lesion

Journal Article

Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Journal Article

Lateral progression of brachial plexus avulsion injury

GU Yudong

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Journal Article

5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction

Journal Article

Seasonal variations in leaf capturing of particulate matter, surface wettability and micromorphology

Huixia WANG, Hui SHI, Yangyang LI, Ya YU, Jun ZHANG

Journal Article

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Journal Article

Identification and selection of resistance to

Lizhen ZHU, Jianying LI, Zhongping XU, Hakim MANGHWAR, Sijia LIANG, Suli LI, Muna ALARIQI, Shuangxia JIN, Xianlong ZHANG

Journal Article